Region-specific RNA mA methylation represents a new layer of control in the gene regulatory network in the mouse brain
نویسندگان
چکیده
Department of Pathology, Institute of Basic Medical Sciences and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, People’s Republic of China BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China State Key Lab of Molecular Oncology, National Cancer Center/Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely unexplored. We performed a transcriptome-wide methylation analysis using the mouse brain to depict its region-specific methylation profile. RNA methy...
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